A Non-Linear Translational Pipeline
The DEVOTE Programme recognises the need for an agile and iterative strategy for the modern translational pathway.
Moving Beyond Linear Development
Unlike typical linear research and development pipelines, the DEVOTE Programme splits the translational pathway into a series of distinct development phases and expertise domains. This ensures that specialist knowledge is not siloed and is properly contextualised at every stage of the process.
In practice, this means that guidance from implementation scientists, health economists, regulatory experts, trialists, and health informaticians is provided to industry across a project's lifecycle, rather than simply at discrete time points as is current common practice. The result is a more integrated, responsive, and ultimately more successful translational process.
Domains of Expertise
The programme has created eight expertise domains that represent specific areas of knowledge and skills. By bringing together specialists from different domains, DEVOTE leverages a diverse range of perspectives to address complex challenges, leading to more effective translation of scientific discoveries into improved patient outcomes.
Genomics
Core competency in genomic medicine, laboratory science, and genetic test development and validation.
Material Sciences
Advanced materials research and novel sensing technologies for diagnostic platforms.
Genome Editing
Expertise in CRISPR-based and related technologies for diagnostic and therapeutic applications.
Implementation Science
Supporting the pathway from research evidence to practical clinical adoption and routine use.
Health Economics
Economic evaluation and cost-effectiveness analysis to ensure sustainable, value-driven diagnostics.
User-Centred Design
Human factors research ensuring diagnostic tools are practical and intuitive for clinical staff and patients.
Health Informatics
Data systems, analytics, and digital infrastructure for integrating genomic results into clinical workflows.
Regulatory, QA & Governance
Quality assurance, regulatory certification, and governance frameworks for clinical-grade diagnostics.
Development Phases
Traditionally, each development phase is undertaken as an independent step in the translational pathway. This can lead to teams working in silos and research projects stalling in the so-called "valley of death" between discovery and clinical deployment. The DEVOTE Programme recognises the inherent interrelatedness and non-linearity of the modern translational pathway. By championing "team science" and facilitating multi-disciplinary and cross-industry collaboration, the potential of achieving real-world implementation and patient benefit is enhanced.
Biomarker Characterisation
Identifying and validating the genetic markers that will form the basis of each diagnostic test.
Assay Development
Creating the laboratory methods and protocols needed to detect the target biomarkers reliably.
Assay Validation
Rigorous testing to confirm the accuracy, sensitivity, and specificity of each assay under controlled conditions.
Assay Optimisation
Refining assays for speed, usability, and cost-effectiveness in preparation for clinical deployment.
Health Informatics
Building the digital infrastructure to deliver test results to clinicians at the point of need.
Implementation Studies
Evaluating real-world clinical performance, workflow integration, and user acceptance in NHS settings.
Health Economics Evaluation
Assessing cost-effectiveness and economic impact to support commissioning decisions.
Regulatory Support
Navigating certification requirements and quality standards for market authorisation.
Explore Our Projects
See how the non-linear pipeline is being applied across three innovative genomic diagnostics projects.
View Projects